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PolyNaut^® TECHNOLOGY

AMPHIPHILIC BLOCK COPOLYMERS

pH 6.2
Controlled biodegradability
Drug release on demand and intracellularly
Ultra-flexible for enhanced tissue penetration
High loading capability

pH 7.4
Polymers composed of GRAS or metabolisable materials
Multivalent and multiplexed targeting (super-selectivity targeting)
High stability in biological fluids

THE BIONIC NANOPARTICLE

Flexible

High stability in biological fluids
Enhanced tissue penetration

Capable

Multiple cargo encapsulation
pH triggered release

Selective

Phenotypic targeting
Delivers to and enters cells of choice

PolyNaut^® MoA

Upon cellular internalisation, PolyNaut^® has a unique endosomal escape mechanism, with a cytosolic release efficiency of ~70% of the loaded compound.

Typically the pH driven dissolution of a 100 nm PolyNaut^® formed in 100 mM PBS corresponds to a transition from 1 particle to about 300k particles (copolymers + loaded compound and salt) corresponding to 1.5 KPaµm-3 of osmotic pressure.

This allows for the release of drugs, proteins, peptides, nucleic acids and even small nanoparticles in the cell with minimal effect on their metabolic activity.

WATCH VIDEO

PolyNaut® TECHNOLOGY

 High stability in biological fluids  Enhanced tissue penetration

 Multiple cargo encapsulation  pH triggered release

 Phenotypic targeting  Delivers to and enters cells of choice

PolyNaut® MoA

Upon cellular internalisation, PolyNaut® has a unique endosomal escape mechanism, with a cytosolic release efficiency of ~70% of the loaded compound.

Typically the pH driven dissolution of a 100 nm PolyNaut® formed in 100 mM PBS corresponds to a transition from 1 particle to about 300k particles (copolymers + loaded compound and salt) corresponding to 1.5 KPaµm-3 of osmotic pressure.